Hormonal Regulation
Breast cancer is the number one cause of cancer death in Hispanic women. It is the second most common cause of cancer death in Caucasian, African-American, Asian/Pacific Islander and American Indian/Alaska Native women.
How do sex hormones affect the blood supply to tumors? And how can that information be used to develop drugs that control the growth of cancerous tumors? Investigators at Dalton hope to answer these questions and develop better understanding and treatment of breast, uterine and prostate cancers.
Research interests in this group include how hormones control the growth of blood vessels from existing blood vessels (angiogenesis) in normal and tumor target tissues. Research focuses on the role of steroid hormones and nuclear receptors in controlling angiogenic growth factors, and in the mechanisms of action of anti-hormones. The intent is to identify hormonally-controlled molecular targets and effective strategies for anti-angiogenic therapy to treat endocrine-related disease.
