Annayya Aroor M.D., Ph.D.
Associate Research Professor, Department of MedicineOffice Location: VA FO33
Office Phone: 573-814-6000_ext 53729
aroora@health.missouri.edu
Research Interests
- Translational control of gene expression
- Mechanisms of alcohol suppression of immune response
- Alcohol and MAP Kinase cascade Histone modifications by ethanol
- Studies on DPP-4 and SGL2 inhibitors in obesity and diabetes
- Angiotensin and aldosterone effects on insulin resistance
- Studies on AT1 receptor antagonist on cardiorenal metabolic syndrome
- Impact of dual acting Angiotensin-receptor/Neprlysin inhibiter therapy on abnormal cardiac, vascular rand renal function in male Zucker obese rats
- Cell specific mineralocorticoid receptors signaling and kidney fibrosis and cardiovascular stiffness
Professional Background
- Assistant Professor, Department of Biochemistry, Kasturba Medical College, Manipal, India 1980 – 1982
- Reader and Head, Department of Clinical Biochemistry and Nutrition 1983 – 1985
- Associate Professor and Head, Department of Clinical Biochemistry and Nutrition 1985 - 1988
- Professor and Head, Department of Clinical Biochemistry and Nutrition 1988 - 1995, 1997- 2005
- Director, Clinical Biochemistry Laboratory, Kasturba Medical College Hospital, Kasturba Medical College, Manipal, India 1983 – 1995, 1997 - 2005
- Research Assistant Professor, Department of Medical Pharmacology and Physiology University of Missouri School of Medicine 2006 - 2011
- Research Assistant Professor, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Center for Diabetes and Cardiovascular Research, Division of Nephrology, University of Missouri, School of Medicine, Columbia, USA 2011- 2020
- Research Associate Professor, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Center for Diabetes and Cardiovascular Research, Division of Nephrology, University of Missouri, School of Medicine, Columbia, USA 2020 to date
Selected Publications
Foote,C A, Soares RN, Ramirez-Perez,F, Ghiarone,T Aroor AR, Manrique-Acevedo C, Padilla J and Martinez-Lemus , Endothelial Glycocalyx Amer J Physiology (in press)
Zhang L, Yang Y, Aroor AR, Jia G, Sun Z, Parrish A, Litherland G, Bonnard B, Jaisser F, Sowers JR, Hill MA. Endothelial sodium channel activation mediatesDOCA-salt-induced endothelial cell and arterial stiffening. Metabolism. 2022 May;130:155165.
Aroor AR, DeMarco VJ, Whaley-Connell AT, Jia J, Yang Y, Sharma N, Hans C, Hayden MR, Hill MA 4,6, Sowers RJ, Manrique-Acevedo C Lastra G Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice. Amer J Physiol. (In press)
Aroor AR, Whaley-Connell A, Sowers JR. Renal resistive index as a novel biomarker for cardiovascular and kidney risk reduction in type II diabetes. J Clin Hypertens (Greenwich). 2020 ;22:231-233.
Das NA, Carpenter AJ, Belenchia A, Aroor AR, Noda M, Siebenlist U, Chandrasekar B, DeMarco VG. Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition. Cell Signal. 2019;68:10950
Aroor AR, Whaley-Connell A, Sowers JR. Utility of obesity and metabolic dyslipidemia (a non-insulin based determinate of the metabolic syndrome and insulin resistance) in predicting arterial stiffness. J Clin Hypertens (Greenwich). 21:1071-1074.
Shukla SD, Restrepo R, Aroor AR, Liu X, Lim RW, Franke JD, Ford DA, Korthuis RJ. Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles. J Pharmacol Exp Ther. 2019;370:390-398.
Aroor AR, Habibi J, Nistala R, Ramirez-Perez FI, Martinez-Lemus LA, Jaffe IZ, Sowers JR, Jia G,Whaley-Connell A. Diet-Induced Obesity Promotes Kidney Endothelial Stiffening and Fibrosis Dependent on the Endothelial Mineralocorticoid Receptor. Hypertension.73:849-858. 2019.
Aroor AR, Das NA, Carpenter AJ, Habibi J, Jia G, Ramirez-Perez FI,Martinez-Lemus L, Manrique-Acevedo CM, Hayden MR, Duta C, Nistala R, Mayoux E,Padilla J, Chandrasekar B, DeMarco VG. Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury. Cardiovasc Diabetol.17:108,2018
Aroor AR, Manrique-Acevedo C, DeMarco VG. The role of dipeptidylpeptidase-4inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin. Cardiovasc Diabetol.17:59.2018.
Aroor AR, Jia G, Sowers JR. Cellular mechanisms underlying obesity-induced arterial stiffness. Am J Physiol Regul Integr Comp Physiol.314:R387-R398.2018.
Jia G, Aroor AR, Sowers JR. The role of mineralocorticoid receptor signaling in the cross-talk between adipose tissue and the vascular wall. Cardiovasc Res. 113:1055-1063. 2017.
Aroor AR, Jia G, Habibi J, Sun Z, Ramirez-Perez FI, Brady B, Chen D, Martinez-Lemus LA, Manrique C, Nistala R, Whaley-Connell AT, Demarco VG, Meininger GA, Sowers JR. Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice. Metabolism.;74:32-40. 2017.
Martinez-Lemus LA, Aroor AR, Ramirez-Perez FI, Jia G, Habibi J, DeMarco VG,Barron B, Whaley-Connell A, Nistala R, Sowers JR. Amiloride Improves Endothelial Function and Reduces Vascular Stiffness in Female Mice Fed a Western Diet. Front Physiol. 8:456. 2017
Lastra G, Manrique C, Jia G, Aroor AR, Hayden MR, Barron BJ, Niles B, Padilla J, Sowers JR. Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice. Am J Physiol Regul Integr Comp Physiol. 313: R67-R77. 2017.
Aroor AR, Habibi J, Kandikattu HK, Garro-Kacher M, Barron B, Chen D, Hayden MR, Whaley-Connell A, Bender SB, Klein T, Padilla J, Sowers JR, Chandrasekar B, DeMarco VG. Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice. Cardiovasc Diabetol. 16:61. 2017
Aroor AR, Habibi J, Ford DA, Nistala R, Lastra G, Manrique C, Dunham MM, Ford KD, Thyfault JP, Parks EJ, Sowers JR, Rector RS. Dipeptidyl peptidase-4inhibition ameliorates western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. Diabetes. 64:1988-2001, 2015.
Aroor AR, Restrepo RJ, Kharbanda KK, Shukla SD. Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury. Hepatol Int.8 Suppl 2:421-30, 2014.
Jia G, Aroor AR, Martinez-Lemus LA, Sowers JR. Overnutrition, mTOR signaling, and cardiovascular diseases Am J Physiol Regul Integr Comp Physiol. 307:R1198-206.2014.
Aroor AR, Restrepo RJ, Kharbanda KK , Shukla SD Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury. Hepatol Int 8 (Suppl 2):S421–S430, 2014.
Aroor AR, DeMarco VG. Oxidative stress and obesity: the chicken or the egg? Diabetes.63:2216-8, 2014.
Aroor AR, Sowers JR, Jia G, DeMarco VG. Pleiotropic Effects of the Dipeptidylpeptidase-4 Inhibitors on the Cardiovascular System. Am J Physiol Heart Circ Physiol.307:H477-92, 2014.
Jia G, Aroor AR, Sowers JR. Arterial Stiffness: A Nexus between Cardiac and Renal Disease. Cardiorenal Med. 4:60-71,2014.
