Taixing Cui, PhD

Research summary

• Posttranslational protein modification and protein quality control
• Super enhancers
• Cell fate and phenotype regulation
• Extracellular microvesicles
• Mechanotransduction

Research interests

Dr. Taixing Cui’s research program is focused on pathobiology contributing to cardiovascular disease. His lab takes multi-disciplinary approaches to explore novel cellular and molecular mechanisms underlying cardiovascular adaptive responses as well as maladaptive remodeling and dysfunction in diverse pathological settings and to identify the novel therapeutic targets for cardiovascular disease.

Lab staff

• Jianxin (Jason) Yan, MD, PhD, Postdoctoral fellow
• Yixiao Liu, PhD, Postdoctoral fellow
• Nathan Schwartz, BS, Lab manager
• Minna Huang, MS, Research Associate
• Xue Jiang, MD, Research Specialist

Select publications

• Wu W, Hendrix A, Nair S, Cui T. Nrf2-mediated dichotomy in the vascular system: Mechanistic and therapeutic perspective. Cells. 2022, 11(19), 3042
• Zang H, Wu W, Qi L, Wenbin Tan, Nagarkatti M, Nagarkatti P, Wang X, Cui T. Autophagy inhibition enables Nrf2 to exaggerate the progression of diabetic cardiomyopathy in mice. Diabetes. 2020 Dec;69(12):2720-2734
• Qi L, Zang H, Wu W, Nagarkatti P, Nagarkatti M, Liu Q, Robbins J, Wang X, Cui T. CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes. J Mol Cell Cardiol. 2020 Jun 14;145:59-73.
• Wu W, Wang C, Zang H, Qi L, Azhar M, Nagarkatti M, Nagarkatti P, Cai G, Weiser-Evans MCM, Cui T. Mature vascular smooth muscle cells, but not endothelial cells, serve as the major cellular source of intimal hyperplasia in vein grafts. Arterioscler Thromb Vasc Biol. 2020 Aug;40(8):1870-1890.
• Qin Q, Qu C, Niu T, Zang H, Lyu L, Wang X, Nagarkatti M, Nagarkatti P, Janicki JS, Wang XL, Cui T. Nrf2-mediated cardiac maladaptive remodeling and dysfunction in a setting of autophagy insufficiency. Hypertension. 2016 Jan;67(1):107-17.