Shinghua Ding, PhD

Research summary

• Ischemic stroke
• Neurodegenerative diseases
• Glia-neuron interactions
• Reactive astrocytes
• Metabolism

Research summary

Ding lab’s research focuses on two areas 1) Brain recovery/repair after ischemic stroke; and 2) Metabolic dysfunction in neurodegenerative diseases (NDs). Combined technologies including in vivo 2-P imaging, metabolomics, RNA-seq, iPSCs, electrophysiology, biochemical assays, transgenic mice, behavioral tests, etc. are used.

Lab staff

• Zhe Zhang, PhD, Postdoctoral fellow
• Nannan Zhang, MS, research specialist
• Shraddha Amatya, MS student

Select publications

• Samuel Lundt, Nannan Zhang, Luis Polo-Parada, Xinglong Wang, and Shinghua Ding. Dietary NMN supplementation enhances motor and NMJ function in ALS. Experimental Neurology 374: 114698, 2024. doi: 10.1016/j.expneurol.2024.114698. PMID: 38266764.
• Nannan Zhang, Zhe Zhang1, Rui He, Hailong Li, Shinghua Ding. GLAST-CreERT2 mediated deletion of GDNF increases brain damage and exacerbates long-term stroke outcomes after focal ischemic stroke in mouse model. Glia 68: 2395-2414, 2020. PMID:32497340. DOI: 10.1002/glia.23848.
• Xiaowan Wang, Qiao Zhang, Ruisi Bao, Nannan Zhang, Luis Polo-Parada, Andrew Tarim, Aidan Alemifar, Xianlin Han, Heather M. Wilkins, Russell H. Swerdlow, Xinglong Wang, Shinghua Ding. Neuronal deletion of Nampt in adult mice leads to motor dysfunction, neurodegeneration, and death. Cell Reports 20: 2184-2200, 2017. PMID:28854367.
• Gourav Roy Choudhury, Shinghua Ding. Reactive astrocytes and therapeutic potential in focal ischemic stroke. Neurobiology of Disease 85: 234-244, 2016 (Invited review). PMID:25982835.
• Hailong Li, Nannan Zhang, Hsinyun Lin, Yang Yu, Quan-Yu Cai, Lixin Ma, and Shinghua Ding*. Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult mice. BMC Neuroscience 15:58, 2014. PMID: 24886391. IMF 3.288.