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Lakshmidevi Pulakat, Ph.D.

List of Faculty Titles
Office Location: DCRC 160
Office Phone: (573) 814-6000
pulakatl@health.missouri.edu

Research Interests

Cardiovascular Disease, Diabetes & Metabolism

Research Description

Cardiovascular Disease, Diabetes & Metabolism

Professional Background

Appointments

  • 2013 - present: Professor of Medical Pharmacology and Physiology, University of Missouri, Columbia MO
  • 2010 - present: Associate Director of Research for the Division of Endocrinology, Diabetes & Metabolism
  • 2010 - present: Professor, Nutrition and Exercise Physiology, University of Missouri, Columbia MO
  • 2009 - present: Professor of Medicine, Department of Internal Medicine, University of Missouri, Columbia, Missouri
  • 2005 - 2009: Professor of Biological Sciences, Department of Biological Sciences, Mississippi State University, Mississippi
  • 2004 - 2005: Professor, Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio
  • 2000 - 2004: Associate Professor, Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio
  • 1995 - 2000: Assistant Professor, Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio
  • 1993 - 1995: Research Associate, Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio

Education

  • 1979: B.Sc., Chemistry, SNGS College, Calicut University, India
  • 1981: M.Sc., Life Sciences, Jawaharlal Nehru University, India
  • 1984: M.Phil., Molecular Biology, DST Unit of Genetic Engineering, Jawaharlal Nehru University, India
  • 1989: Ph.D., Biochemistry and Molecular Biology, Russel Grimwade School of Biochemistry, University of Melbourne, Australia
  • 1993: Post-doctoral fellowship, Signal Transduction, Department of Neurobiology and Behavior (Psychobiology), University of California, Irvine, California

Selected Publications

Journal Articles

  1. Erickson CE, Gul R, Blessing CP, Nguyen J, Liu T, Pulakat L, Bastepe M, Jackson EK, Andreson BT. (2013) The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist. PLoS ONE 8(8): e71980. doi:10.1371/journal.pone.0071980 
  2. Nistala R, Andresen BT, Pulakat L, Meuth A, Sinak C, Mandavia C, Thekkumkara T, Speth RC, Whaley-Connell AT, Sowers JR. (2013) Angiotensin Type 1 Receptor Resistance To Blockade In The Opossum Proximal Tubule Cell Due To Variations In The Binding Pocket. Am J Physiol Renal Physiol. 2013 Feb 6. 304(8):F1105-13 
  3. Gul R, Ramdas M, Mandavia C, Sowers JR and Pulakat L. RAS-mediated adaptive mechanisms in cardiovascular tissues: Confounding factors of RAS blockade therapy and alternative approaches. Cardiorenal Med, (4):268-280 (Featured in MD LINX 2/22/2013) 
  4. Pulakat L, Aroor AR, Gul R, Sowers JR. Cardiac insulin resistance and microRNA modulators. Exp Diabetes Res. 2012;2012:654904 
  5. Gul R, DeMarco VG, Sowers JR Whaley-Connell AT and Pulakat L (2012). Regulation of over-nutrition induced cardiac inflammatory mechanisms by nebivolol. Cardiorenal Med, 2:225-233 
  6. Mandavia CH, Pulakat L, Demarco V, Sowers JR. Over-nutrition and metabolic cardiomyopathy. Metabolism. 2012 Sep;61(9):1205-10.
  7. Whaley-Connell A, Habibi J, Nistala R, Hayden MR, Pulakat L, Sinak C, Locher B, Ferrario CM, Sowers JR. Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat. Regul Pept. 2012 Jun 10;176(1-3):36-44 
  8. Aroor AR, Mandavia C, Ren J, Sowers JR. and Pulakat L. Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome. Cardiorenal Med 2012;2:87-109 
  9. Ma L, Gul R, Habibi J, Yang M, Pulakat L, Whaley-Connell A, Ferrario CM, Sowers JRNebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat. Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2341-51 
  10. DeMarco VG, Johnson MS, Ma L, Pulakat L, Mugerfeld I, Hayden MR, Garro M, Knight W, Britton SL, Koch LG, Sowers JR. Overweight female rats selectively breed for low aerobic capacity exhibit increased myocardial fibrosis and diastolic dysfunction. Am J Physiol Heart Circ Physiol. 2012 Apr 15;302(8):H1667-82. 
  11. Gavini N., Delacroix S, Harris K and Pulakat L. Discovery of Evolutionary Divergence of Biological Nitrogen Fixation and Photosynthesis: Fine Tuning of Biogenesis of the NifH and the ChlL by a Peptidyl-Prolyl Cis/Trans Isomerase (2011) Am. J. Biochem. Biotech. 7. 196-203 
  12. Habibi, J., DeMarco, V.G., Ma, L., Pulakat, L, Rainey, W.E., Whaley-Connell, A.T., Sowers, J.R. (2011) Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in transgenic model of RAAS over-expression. Am J Physiol Heart Circ Physiol, 300, H148-91 
  13. Pulakat, L, Aroor, A., Gul, R. Sowers, JR (2011). Cardiac Insulin Resistance and microRNA Modulators. Exp. Diabetes Res. Special Issue Pathophysiological Insights into Cardiovascular Health in Metabolic Syndrome. 2012;2012:654904 
  14. Pulakat L, DeMarco VG, Ardhanari S, Chockalingam A, Gul R, and Sowers JR (2011). Signaling Mechanisms to compensate for cardiovascular abnormalities in over-nutrition. Invited review, Am J Physiol-Reg, Int, and Comp Physiol, 2011 Oct;301(4):R885-95 
  15. Hayden MR, Sowers KM, Pulakat L, Joginpally T, Krueger B, Whaley-Connell A, Sowers JR. Possible Mechanisms of Local Tissue Renin-Angiotensin System Activation in the Cardiorenal Metabolic Syndrome and Type 2 Diabetes Mellitus. Cardiorenal Med. 2011;1(3):193-210 
  16. DeMarco, V., Johnson, M, Habibi, J., Pulakat, L, Gul, R., Hayden, M. R., Tilmon, R., Dellsperger, K., Weiner, N., Whaley-Connell, A. and Sowers, J. R. (2011). Comparative Analysis of Telmisartan and Olmesartan on Cardiac Function in the TG(mRen2)27 Rat. Am J Physiol Heart Circ Physiol. 300(1):H181-90 
  17. Habibi, J., Hayden, M. R., Sowers, J. R., Pulakat, L, Elliott, D., Tilmon, R., Manrique, C., Lastra, G., DeMarco, V., and Whaley-Connell, A. (2011) Nebivolol attenuates redox-sensitive glomerular and tubular mediated proteinuria in obese rats. Endocrinology. 152 (2): 659-68 
  18. Habibi, J., DeMarco, VG., Ma, L., Pulakat, L, Rainey WE, Whaley-Connell AT,, and Sowers JR. (2011) Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in transgenic model of RAAS overexpression. Am J Physiol Heart Circ Physiol. (Epub ahead of print) 
  19. Manrique, C., Lastra, G., Habibi, J., Pulakat, L, Schneider, R., Durante, W., Tilmon, R., Rehmer, J., Hayden, M. R., Ferrario, C. M., Whaley-Connell, A., Sowers, J.R.(2011) Nebivolol improves insulin sensitivity in the TGR(Ren2)27 rat. Metabolism. Jun 1. [Epub ahead of print] 
  20. Whaley-Connell, A., Pulakat, L, DeMarco, VG., Hayden, M.R., Habibi, J., Henriksen, E.J., and Sowers, J.R. (2011) Overnutrition and the Cardiorenal Syndrome: Use of a Rodent Model to Examine Mechanisms. Cardiorenal Med. 1:23-30 

Published by Dalton Cardiovascular Research Center, 134 Research Park Dr., Columbia, MO 65211
Phone: 573-882-7588 | Fax: 573-884-4232 | Email: dalton@missouri.edu