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Nicole L. Nichols, Ph.D.

Assistant Professor, Department of Biomedical Sciences
Office Location: W145 Vet Med
Office Phone: 573-882-2534

Research Interests

Breathing, Hypoxia, Plasticity, and Motor Neuron Death

Research Description

The primary focus of our laboratory concerns mechanisms of neuroplasticity, specifically in the respiratory motor control system in models of motor neuron death, including ALS.

Professional Background

2/2015-present Assistant professor, Department of Biomedical Sciences, University of Missouri, Columbia, MO

2014-2015 Research Associate in Respiratory Neurobiology, University of Wisconsin-Madison, Madison, WI

2008-2014 Post-doctoral Fellow in Respiratory Neurobiology, University of Wisconsin-Madison, Madison, WI 

2008 Ph.D. in Biomedical Sciences with concentration in Neuroscience and Physiology, Wright State University Boonshoft School of Medicine, Dayton, OH 

2003 B.S. in Life Science with concentration in Molecular Biology and Health Sciences with Distinction, Otterbein College, Westerville, OH 

Selected Publications

1. Satriotomo, I., Nichols, N.L., Dale, E.A., Emery, A.T., Dahlberg, J. and Mitchell, G.S. Repetitive acute intermittent hypoxia increases growth/neurotrophic factor expression in non-respiratory motor neurons. In revision at Neuroscience.

2. Nichols, N.L., Satriotomo, I., Harrigan, D.J. and Mitchell, G.S. (2015). Acute intermittent hypoxia induced phrenic long-term facilitation despite increased SOD1 expression in a rat model of ALS. Exper. Neurol. 273: 138-150.

3. Nichols, N.L., Vinit, S., Bauernschmidt, L. and Mitchell, G.S. (2015). Respiratory function after selective respiratory motor neuron death from intrapleural CTB-saporin injections. Exper. Neurol. 267: 18-29.

4. Nichols, N.L., Johnson, R.A., Satriotomo, I. and Mitchell, G.S. (2014). Neither serotonin nor adenosine-dependent mechanisms preserve ventilatory capacity in ALS rats. Respir. Physiol. Neurobiol. 197: 19-28.

5. Nichols, N.L. and Sasser, J.M. (2014). The other side of the submit button: how to become a reviewer for scientific journals. Physiologist. 57(2): 88-91.

6. Nichols, N.L., Powell, F.L., Dean, J.B. and R.W. Putnam. (2014). Substance P differentially modulates firing rate of solitary complex (SC) neurons from control and chronic hypoxia-adapted adult rats. PLoS ONE. 9(2): e88161.

7. Nichols, N.L., Van Dyke, J., Suzuki, M. and Mitchell, G.S. (2013). Ventilatory control in ALS. Respir. Physiol. Neurobiol. 183(2): 429-437.

8. Devinney, M.J., Huxtable, A.G., Nichols, N.L. and Mitchell, G.S. (2013). Hypoxia-induced phrenic long-term facilitation: emergent properties. Ann. N Y Acad. Sci. 1279(1): 143-153.

9. Nichols, N.L., Gowing, G., Satriotomo, I., Nashold, L.J., Dale, E.A., Suzuki, M., Avalo, P., Mulcrone, P.L., McHugh, J., Svendsen, C.N. and Mitchell, G.S. (2013). Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of ALS. Am. J. Resp. Crit. Care Med. 187(5): 535-542.

Published by Dalton Cardiovascular Research Center, 134 Research Park Dr., Columbia, MO 65211
Phone: 573-882-7588 | Fax: 573-884-4232 | Email: