M. Harold Laughlin, PhD
Professor and Chair, Department of Biomedical SciencesAdjunct Professor, Department of Medical Pharmacology and Physiology
Office Location: E102 Veterinary Medicine
Office Phone: 573-882-7011
LaughlinM@missouri.edu
Research Interests
Research Description
The training-induced changes in vascular transport capacity are associated with growth of new capillaries, enlargement of arteries and veins, and alterations in factors that control blood flow in the heart and skeletal muscle. The lab is currently investigating the mechanisms responsible for these changes. Studies are conducted with: isolated hearts, isolated muscle tissue, single blood vessels and in conscious, chronically instrumented animals during exercise. To allow examination of the relationship among vascular adaptations and the response of the myocytes to training-induced increases in the functional demands of the muscles, the effects of training on biochemical and histological characteristics of the muscles are also measured. Laughlin's research supported by the PPG evaluates the role of exercise training-induced changes in endothelial phenotype in the protective effects of exercise on atherosclerotic coronary artery disease.
Professional Background
- Obtained PhD, University of Iowa.
- Obtained BA, Simpson College.
Selected Publications
- Johnson, L. R., J. W. E. Rush, J. R. Turk, E. M. Price, and M. H. Laughlin. Short-term exercise training increases Ach-induced relaxation and eNOS protein in porcine pulmonary arteries. J. Appl. Physiol., 90: 1102-1110, 2001.
- Schrage, W. G. CR Woodman, and Laughlin MH: Mechanisms of flow and ACh-induced dilation in rat soleus arterioles are altered by hindlimb unweighting. J. Appl. Physiol., 92:901-911, 2002.
- Aaker, A. and Laughlin M. H. Diaphragm arterioles are less responsive to a1-adrenergic constriction than gastrocnemius arterioles. J. Appl. Physiol., 92:1808-1816, 2002.
- Woodman, C. R., J. R. Turk, James W. E. Rush, and Laughlin M. H. Exercise attenuates the effects of hypercholesterolemia on endothelium-dependent relaxation in coronary arteries from adult female pigs. J. Appl. Physiol., 96:1105-1113, 2004.
- Thompson, M. A., K. K. Henderson, C. R. Woodman, J. R. Turk, James W. E. Rush, and M. H. Laughlin. Exercise Preserves Endothelium-Dependent Relaxation in Coronary Arteries of Hypercholesterolemic Male Pigs. J. Appl. Physiol., 96:1114-1126, 2004.
- Laughlin M.H. Joseph B. Wolfe Memorial lecture. Physical Activity in Prevention and Treatment of Coronary Disease: The Battle Line is in Exercise Vascular Cell Biology. Med. & Sci. In Sports & Exercise. 36:352-362, 2004.