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Li-Qun (Andrew) Gu, PhD

Associate Professor, Bioengineering
Office Location: 221 DCRC
Office Phone: 573-882-2057

Research Interests

Single-molecule detection, Nanopore, ion channels, Biochip for Molecular diagnostics, Point-of-care, Epigenetics, and Personalized medicine, and Membrane biophysics

Research Description

Dr. Li-Qun (Andrew) Gu, an Associate Professor of Bioengineering and Dalton Cardiovascular Research Center, is leading an interdisciplinary laboratory that has a long term vision: integrating biomolecular engineering with nanobiotechnology to explore life science problems and to develop sophisticated molecular diagnostic tools for personalized medicine. Dr. Gu is an awardee of NSF CAREER. Supported by the NIH grant and Coulter Translational Program, he is developing ultrasensitive single molecule technology for disease biomarker detection. His lab is working on nanopore-based single-molecule technology for rapid, label-free and low-cost DNA sequencing and various genetic, epigenetic, and proteomic detections. The new generation of programmable nanopore biosensors is being combined with smart polymers and microfludics to create robust chip device for medical diagnosis, treatment, and high-throughput screening at the molecular level. Recently, His lab proposed a robust nanopore sensor for differentiating and quantifying cancer-associated microRNAs in human blood samples, an approach with the potential in non-invasive and cost-effective cancer detection (Nat.Nano. 2011, ACS Nano 2013, and ACS Nano 2014). MicroRNAs and a series of epigenetically modified gene are potential biomarkers for molecular diagnostic of cancers. (new input) This esearch is being expanded to various RNA detections in life science, plant science, agriculture, food safety detection, and environmental engineering.

Professional Background

  • Obtained PhD in biological photonics, Nankai University.
  • Obtained MS in molecular biophysics, Nankai University.
  • Obtained BS in biological and medical physics, Nankai University.

Selected Publications

Published by Dalton Cardiovascular Research Center, 134 Research Park Dr., Columbia, MO 65211
Phone: 573-882-7588 | Fax: 573-884-4232 | Email: