Li-Qun (Andrew) Gu, PhD
Associate Professor, Biological EngineeringOffice Location: 229 Dalton Cardiovascular Research Center
Office Phone: 573-882-2057
GuL@missouri.edu
Research Interests
Nanopore-based Single Molecule Detection
Research Description
The Nano-Biotech Group is developing a novel technology for single molecule detection by using using engineered Nanopore, which can be used to solve biomedical problems, e.g. tracking cellular components, probing biochemical reaction, investigating bio-transportation, protein-ligand recognition, special properties of designed biopolymers, detecting pharmaceuticals and pathogen traces. The Nanopore-based Single Molecule Detection could also play important role in proteomics and genomics. Pico-ampere (10-12 A) current recording technique and molecular biology are applied, and will combine with nanofabrication and bio-MEMS in the future.
Professional Background
- Obtained PhD in biological photonics, Nankai University.
- Obtained MS in molecular biophysics, Nankai University.
- Obtained BS in biological and medical physics, Nankai University.
Selected Publications
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Wang Y, Zheng D, Tan Q, Wang MX, Gu LQ.,Nanopore-based detection of circulating microRNAs in lung cancer patients., Nat Nanotechnol. 2011 Sep 4. doi: 10.1038/nnano.2011.147. [Epub ahead of print]PMID: 21892163
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Tan Q, Shim JW, Gu LQ., Separation of heteromeric potassium channel Kcv towards probing subunit composition-regulated ion permeation and gating., FEBS Lett. 2010 Apr 16;584(8):1602-8. Epub 2010 Mar 18.PMID: 20303961
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Gu LQ, Shim JW., Single molecule sensing by nanopores and nanopore devices., Analyst. 2010 Mar;135(3):441-51. Epub 2009 Dec 22. Review.PMID: 20174694
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Gu LQ, Ding S, Gao C., Aptamer-encoded nanopore for ultrasensitive detection of bioterrorist agent ricin at single-molecule resolution., Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6699-702. Review.PMID: 19964179
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Ding S, Gao C, Gu LQ., Capturing single molecules of immunoglobulin and ricin with an aptamer-encoded glass nanopore., Anal Chem. 2009 Aug 15;81(16):6649-55.PMID: 19627120
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Shim JW, Tan Q, Gu LQ., Single-molecule detection of folding and unfolding of the G-quadruplex aptamer in a nanopore nanocavity., Nucleic Acids Res. 2009 Feb;37(3):972-82. Epub 2008 Dec 26.PMID: 19112078
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Gao C, Ding S, Tan Q, Gu LQ., Method of creating a nanopore-terminated probe for single-molecule enantiomer discrimination., Anal Chem. 2009 Jan 1;81(1):80-6.PMID: 19061410