Li-Qun (Andrew) Gu, PhD
Assistant Professor, Biological EngineeringOffice Location: 229 Dalton Cardiovascular Research Center
Office Phone: 573-882-2057
GuL@missouri.edu
Research Interests
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Research Description
The Nano-Biotech Group is developing a novel technology for single molecule detection by using using engineered Nanopore, which can be used to solve biomedical problems, e.g. tracking cellular components, probing biochemical reaction, investigating bio-transportation, protein-ligand recognition, special properties of designed biopolymers, detecting pharmaceuticals and pathogen traces. The Nanopore-based Single Molecule Detection could also play important role in proteomics and genomics. Pico-ampere (10-12 A) current recording technique and molecular biology are applied, and will combine with nanofabrication and bio-MEMS in the future.
Professional Background
- Obtained PhD in biological photonics, Nankai University.
- Obtained MS in molecular biophysics, Nankai University.
- Obtained BS in biological and medical physics, Nankai University.
Selected Publications
- Gu L.Q., Braha O., Conlan S., Cheley S., and Bayley H., Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter, Nature, 398, 686-690 (1999).
- Gu L.Q., Serra M.D., Vincent J.B., Vigh G., Cheley S., Braha O., and Bayley H., Reversal of charge selectivity in transmembrane protein pores by using non-covalent molecular adapters, Proceedings of National Academy of Science USA, 97, 3959-3964 (2000).
- Braha O., Gu L.Q., Zhou L., Lu X.F., Cheley S., and Bayley H., Simultaneous stochastic sensing of divalent metal ions, Natural Biotechnology, 18, 1005-1007 (2000).
- Gu L.Q., Cheley S., and Bayley H., Capture a single molecule in a nanocavity, Science, 291, 636-640 (2001).
- Cheley S., Gu L.Q. (contribution equally) and Bayley H., Stochastic sensing of nanomolar inosital 1,4,5-triphosphate with an engineered pore, Chemistry & Biology, 9 (7), 829-838 (2002).
- Gu L.Q., Cheley S., and Bayley H., Electroosmotic enhancement of the binding of a neutral molecule to a transmembrane pore, Proceedings of National Academy of Science USA, 100 (26), 15498-15503 (2003).