George E. Davis, MD, PhD
Professor of Medical Pharmacology and PhysiologyMargaret Proctor Mulligan Professor in Medical Research
Office Location: Ma415 Medical Science Bldg
Office Phone: 573-882-5474
DavisGeo@missouri.edu
Research Interests
Davis' laboratory focuses on the following questions relevant to angiogenesis, wound repair and cancer research:
Research Description
Professional Background
- BS in microbiology, Arizona State University
- MD, PhD, University of California, San Diego, PhD in Biology- Role of extracellular matrix in neurite outgrowth
- Anatomic Pathology Residency- National Institutes of Health
- Postdoctoral Research- Burnham Institute, La Jolla, CA
- Assistant to Full Professor, Department of Pathology, Texas A&M College of Medicine
- Past chairperson and member, NIH Cardiovascular Differentiation and Development study section
- Past member, NIH Pathology A study section
- Research funded by the National Institutes of Health
Selected Publications
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Yuan L, Sacharidou A, Stratman AN, Le Bras A, Zwiers PJ, Spokes K, Bhasin M, Shih SC, Nagy JA, Molema G, Aird WC, Davis GE, Oettgen P., RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG., Blood. 2011 Jul 28;118(4):1145-53. Epub 2011 May 31. PMID: 21628409
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Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY., Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.,J Clin Invest. 2011 May 2;121(5):1871-81. doi: 10.1172/JCI44393. Epub 2011 Apr 1.PMID: 21490399
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Davis GE, Stratman AN, Sacharidou A, Koh W., Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting., Int Rev Cell Mol Biol. 2011;288:101-65. doi: 10.1016/B978-0-12-386041-5.00003-0. Review.PMID: 21482411
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Xu K, Sacharidou A, Fu S, Chong DC, Skaug B, Chen ZJ, Davis GE, Cleaver O, Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling., Dev Cell. 2011 Apr 19;20(4):526-39. Epub 2011 Mar 10., PMID: 21396893
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Stratman AN, Davis MJ, Davis GE., VEGF and FGF prime vascular tube morphogenesis and sprouting directed by hematopoietic stem cell cytokines., Blood. 2011 Apr 7;117(14):3709-19. Epub 2011 Jan 14.PMID: 21239704
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Davis GE., Vascular balancing act: EGFL7 and Notch., Blood. 2010 Dec 23;116(26):5791-3. No abstract available.PMID:21183697
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Chao JT, Gui P, Zamponi GW, Davis GE, Davis MJ., Spatial association of the Cav1.2 calcium channel with α5β1-integrin.,Am J Physiol Cell Physiol. 2011 Mar;300(3):C477-89. Epub 2010 Dec 22.PMID: 21178109
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Stratman AN, Schwindt AE, Malotte KM, Davis GE., Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization., Blood. 2010 Nov 25;116(22):4720-30. Epub 2010 Aug 25.PMID: 20739660
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Gui P, Chao JT, Wu X, Yang Y, Davis GE, Davis MJ., Coordinated regulation of vascular Ca2+ and K+ channels by integrin signaling., Adv Exp Med Biol. 2010;674:69-79. Review.PMID: 20549941
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Davis GE., The development of the vasculature and its extracellular matrix: a gradual process defined by sequential cellular and matrix remodeling events., Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H245-7. Epub 2010 Jun 11. No abstract available. PMID: 20543090
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Sacharidou A, Koh W, Stratman AN, Mayo AM, Fisher KE, Davis GE., Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events., Blood. 2010 Jun 24;115(25):5259-69. Epub 2010 Mar 9.PMID:20215637
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Fisher KE, Sacharidou A, Stratman AN, Mayo AM, Fisher SB, Mahan RD, Davis MJ, Davis GE., MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices.,J Cell Sci. 2009 Dec 15;122(Pt 24):4558-69. Epub 2009 Nov 24.PMID: 19934222
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Yang Y, Wu X, Gui P, Wu J, Sheng JZ, Ling S, Braun AP, Davis GE, Davis MJ., Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation., J Biol Chem. 2010 Jan 1;285(1):131-41. Epub 2009 Nov 3.PMID: 19887442
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Kamei, M., Saunders. W.B., Bayless, K.J., Dye, L., Davis. G.E., and Weinstein, B.M. (2006) Endothelial tubes assemble from intracellular vacuoles in vivo. Nature, 442: 453-456.
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Saunders, W.B., Bohnsack, B.L., Faske, J.B., Anthis, N.J., Bayless, K.J., Hirschi, K.K. and Davis, G.E. (2006) Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J. Cell Biol., in press.
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Davis, G.E. and Saunders, W.B. (2006) Molecular balance of capillary tube formation versus regression in wound repair: Role of matrix metalloproteinases and their inhibitors. J. Invest. Dermatol., in press.
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Davis, G.E., and Senger, D.R. (2005) Endothelial-ECM: Biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ. Res., 97:1093-1107.
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Saunders, W.B., Bayless, K.J. and Davis, G.E. (2005) MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices. J. Cell Sci., 118: 2325-2340.
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Bayless, K.J., and Davis, G.E. (2004) Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho. J. Biol. Chem., 279: 11686-11695.
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Bayless, K.J. and Davis, G.E. (2002) The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices, J. Cell Sci., 115:1123-1136.
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Davis, G.E., Bayless, K.J., and Mavila, A. (2002) The molecular basis of endothelial cell morphogenesis in three-dimensional extracellular matrices, Anat. Rec., 268:252-275.
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Davis, G.E., Bayless, K.J., Davis, M.J., and Meininger, G.A. (2000) Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules, Am. J. Pathol., 156:1489-1498.