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George E. Davis, MD, PhD

Professor of Medical Pharmacology and Physiology
Margaret Proctor Mulligan Professor in Medical Research
 Office Location: Ma415 Medical Science Bldg
Office Phone: 573-882-5474
DavisGeo@missouri.edu

Research Interests

Davis' laboratory focuses on the following questions relevant to angiogenesis, wound repair and cancer research:

  • How do endothelial cells form cell-lined tube structures with lumens in three-dimensional (3D) extracellular matrices?
  • How do endothelial cells and other cell types such as tumor cells invade 3D matrices?
  • To what extent do endothelial cells directly or indirectly play a role in tumor invasion and metastasis?
  • What molecular events control the process of vascular regression?
  • How do vascular supporting cells such as pericytes stabilize vascular tubes?
  • How do distinct matrix metalloproteinases and their inhibitors control the processes of vascular morphogenesis versus regression in 3D matrices?
  • How do extracellular matrix fragments (matricryptins) regulate vascular morphogenesis versus regression in normal versus diseased states (e.g. diabetes)?

Research Description

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Professional Background

  • BS in microbiology, Arizona State University
  • MD, PhD, University of California, San Diego, PhD in Biology- Role of extracellular matrix in neurite outgrowth
  • Anatomic Pathology Residency- National Institutes of Health
  • Postdoctoral Research- Burnham Institute, La Jolla, CA
  • Assistant to Full Professor, Department of Pathology, Texas A&M College of Medicine
  • Past chairperson and member, NIH Cardiovascular Differentiation and Development study section
  • Past member, NIH Pathology A study section
  • Research funded by the National Institutes of Health

Selected Publications

  • Kamei, M., Saunders. W.B., Bayless, K.J., Dye, L., Davis. G.E., and Weinstein, B.M. (2006) Endothelial tubes assemble from intracellular vacuoles in vivo. Nature, 442: 453-456.
  • Saunders, W.B., Bohnsack, B.L., Faske, J.B., Anthis, N.J., Bayless, K.J., Hirschi, K.K. and Davis, G.E. (2006) Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J. Cell Biol., in press.
  • Davis, G.E. and Saunders, W.B. (2006) Molecular balance of capillary tube formation versus regression in wound repair: Role of matrix metalloproteinases and their inhibitors. J. Invest. Dermatol., in press.
  • Davis, G.E., and Senger, D.R. (2005) Endothelial-ECM: Biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ. Res., 97:1093-1107.
  • Saunders, W.B., Bayless, K.J. and Davis, G.E. (2005) MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices. J. Cell Sci., 118: 2325-2340.
  • Bayless, K.J., and Davis, G.E. (2004) Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho. J. Biol. Chem., 279: 11686-11695.
  • Bayless, K.J. and Davis, G.E. (2002) The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices, J. Cell Sci., 115:1123-1136.
  • Davis, G.E., Bayless, K.J., and Mavila, A. (2002) The molecular basis of endothelial cell morphogenesis in three-dimensional extracellular matrices, Anat. Rec., 268:252-275.
  • Davis, G.E., Bayless, K.J., Davis, M.J., and Meininger, G.A. (2000) Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules, Am. J. Pathol., 156:1489-1498.

Published by Dalton Cardiovascular Research Center, 134 Research Park Dr., Columbia, MO 65211
Phone: 573-882-7588 | Fax: 573-884-4232 | Email: dalton@missouri.edu
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