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Frank W. Booth, PhD

Professor, Department of Biomedical Sciences
Office Location: W145 Veterinary Medicine
Office Phone: 573-882-6652
BoothF@missouri.edu

Research Interests

Physiological, biochemical, molecular and genetic adaptations to altered usage of skeletal muscle

Research Description

Research interests in my laboratory currently focus on two areas.

First, we are addressing the question: what is the identity of genes in the nucleus accumbens that motivate rats that were bred to be “born-to-run” to have long distances of voluntary running in wheels, as compared to other rats that were bred to mimic “couch potato” behavior by having low distances of voluntary running?

 

Second, we are tackling the questions: 1) does voluntary running in wheels produce higher peak lifetime aerobic capacities than in rats without wheels for voluntary running; 2) does voluntary running attenuate primary aging-induced loss of aerobic capacity; and 3) which genes are responsible for the previous two questions?

 

Professional Background

  • Obtained BS in biology, Denison University.
  • Obtained PhD in exercise physiology, University of Iowa.
  • Completed postdoctoral fellowship at the School of Aerospace Medicine.
  • Completed postdoctoral fellowship at Washington University.
  • Received National Institute of Health (NIH) MERIT Award.
  • Member of editorial boards for Journal of Applied Physiology, American Journal of Physiology: Cell Physiology, Physiological Genomics, and CardioMetabolic Syndrome.
  • Member of Respiratory and Applied Physiology study sections of the NIH.
  • Research funded by NIH.

Selected Publications

  • Roberts MD, Cruthirds CL, Lockwood CM, Pappan K, Childs TE, Company JM, Brown JD, Toedebusch RG, Booth FW. Comparing serum responses to acute feedings of an extensively hydrolyzed whey protein concentrate versus a native whey protein concentrate in rats: a metabolomics approach. Appl Physiol Nutr Metab. 39:158-167, 2014.

  • Linden MA, Fletcher JA, Morris EM, Meers GM, Kearney ML, Crissey JM, Laughlin MH, Booth FW, Sowers JR, Ibdah JA, Thyfault JP, Rector RS. Combining Metformin and Aerobic Exercise Training in the Treatment of Type 2 Diabetes and NAFLD in OLETF Rats. Am J Physiol Endocrinol Metab. 306:E300-310, 2014.

  • Company JM, Roberts MD, Toedebusch RG, Cruthirds CL, Booth FW. Sudden decrease in physical activity evokes adipocyte hyperplasia in 70- to 77-day-old rats but not 49- to 56-day-old rats. Am J Physiol Regul Integr Comp Physiol. 305:R1465-78, 2013.

  • Fain JN, Company JM, Booth FW, Laughlin MH, Padilla J, Jenkins NT, Bahouth SW, Sacks HS. Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs. Metabolism.62:1503-1511, 2013.

  • Padilla J, Jenkins NT, Lee S, Zhang H, Cui J, Zuidema MY, Zhang C, Hill MA, Perfield JW 2nd, Ibdah JA, Booth FW, Davis JW, Laughlin MH, Rector RS. Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine. Physiol Genomics. 45:434-446, 2013

  • Roberts MD, Brown JD, Company JM, Oberle LP, Heese AJ, Toedebusch RG, Wells, KD, Cruthirds CL, Knouse JA, Ferreira JA, Childs TE, Brown M, Booth FW. Phenotypic And Molecular Differences Between Rats Selectively-Bred To Voluntarily Run High Versus Low Nightly Distances. Am J Physiol Regul Integr Comp Physiol. 304:R1024-1035, 2013.

    Linden MA, Meers GM, Ruebel ML, Jenkins NT, Booth FW, Laughlin MH, Ibdah JA, Thyfault JP, Rector RS. Hepatic Steatosis Development with Four Weeks of Physical Inactivity in Previously Active, Hyperphagic OLETF Rats. Am J Physiol Regul Integr Comp Physiol. 304:R763-771, 2013.

  • Roberts MD, Bayless DS, Company JM, Jenkins NT, Padilla J, Childs TE, Martin JS, Dalbo VJ, Booth FW, Rector RS, Laughlin MH. Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats. Metabolism. 62:1052-1056, 2013.

  • Zwetsloot KA, Childs TE, Gilpin LT, Booth FW. Non-passaged muscle precursor cells from 32-month old rat skeletal muscle have delayed proliferation and differentiation. Cell Prolif. 46:45-57, 2013.

  • Jenkins NT, Padilla J, Arce-Esquivel AA, Bayless DS, Martin JS, Leidy HJ, Booth FW, Rector RS, Laughlin MH. Effects of endurance exercise training, metformin, and their combination on adipose tissue leptin and IL-10 secretion in OLETF rats. J Appl Physiol. 113:1873-83, 2012

  • Morris EM, Meers GM, Booth FW, Fritsche KL, Hardin CD, Thyfault JP, Ibdah JA. PGC-1α Overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion. Am J Physiol Gastrointest Liver Physiol. 303:G979-992, 2012.

  • Padilla J, Jenkins NT, Roberts MD, Arce-Esquivel AA, Martin JS, Laughlin MH, and Booth FW. Differential changes in vascular mRNA levels between rat iliac and renal arteries produced by cessation of voluntary running. Exp Physiol. 98:337-347, 2013.

  • Park Y, Booth FW, Lee S, Laye MJ, Zhang C. Physical Activity Opposes Coronary Vascular Dysfunction Induced during High Fat Feeding in Mice. J Physiol. 590:4255-4268, 2012.

  • Toedebusch RG, Childs TE, Hamilton SR, Crowley JR, Booth FW, Roberts MD. Postprandial leucine and insulin responses and toxicological effects of a novel whey protein hydrolysate-based supplement in rats. J Int Soc Sports Nutr. 6;9(1):24, 2012.

  • Brown JD, Naples SP, Booth FW. Effects of voluntary running on oxygen consumption, RQ, and energy expenditure during primary prevention of diet-induced obesity in C57BL/6N mice. J Appl Physiol. 113:473-478, 2012.

  • Zwetsloot KA, Nedergaard A, Gilpin LT, Childs TE, Booth FW. Differences in transcriptional patterns of extracellular matrix, inflammatory, and myogenic regulatory genes in myofibroblasts, fibroblasts, and muscle precursor cells isolated from old male rat skeletal muscle using a novel cell isolation procedure. Biogerontology 13:383-398, 2012.

  • Roberts MD, Childs TE, Brown JD, Davis JW, Booth FW. Early depression of Ankrd2 and Csrp3 mRNAs in the polyribosomal and whole-tissue fractions in skeletal muscle with decreased voluntary running. J Appl Physiol. 112:1291-1299, 2012.

  • Mikus CR, Oberlin DJ, Libla JL, Taylor AM, Booth FW, Thyfault JP. Lowering Physical Activity Impairs Glycemic Control in Healthy Volunteers. Med Sci Sports Exerc. 44:225-231, 2012.

  • Booth FW, Hargreaves M., Understanding multi-organ pathology from insufficient exercise., J Appl Physiol. 2011 Aug 18. [Epub ahead of print]PMID: 21852409
  • Booth FW, Laye MJ, Roberts MD., Lifetime sedentary living accelerates some aspects of secondary aging., J Appl Physiol. 2011 Aug 11. [Epub ahead of print]PMID: 21836048
  • Mikus CR, Oberlin DJ, Libla JL, Taylor AM, Booth FW, Thyfault JP., Lowering Physical Activity Impairs Glycemic Control in Healthy Volunteers., Med Sci Sports Exerc. 2011 Jun 28. [Epub ahead of print]PMID:21716152
  • Thyfault JP, Booth FW., Lack of regular physical exercise or too much inactivity., Curr Opin Clin Nutr Metab Care. 2011 Jul;14(4):374-8.PMID: 21519238
  • Rector RS, Uptergrove GM, Morris EM, Borengasser SJ, Laughlin MH, Booth FW, Thyfault JP, Ibdah JA., Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model., Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G874-83. Epub 2011 Feb 24.PMID:21350190
  • Company JM, Booth FW, Laughlin MH, Arce-Esquivel AA, Sacks HS, Bahouth SW, Fain JN., Epicardial fat gene expression after aerobic exercise training in pigs with coronary atherosclerosis: relationship to visceral and subcutaneous fat., J Appl Physiol. 2010 Dec;109(6):1904-12. Epub 2010 Oct 14.PMID: 20947714
  • Mikus CR, Rector RS, Arce-Esquivel AA, Libla JL, Booth FW, Ibdah JA, Laughlin MH, Thyfault JP., Daily physical activity enhances reactivity to insulin in skeletal muscle arterioles of hyperphagic Otsuka Long-Evans Tokushima Fatty rats.,J Appl Physiol. 2010 Oct;109(4):1203-10. Epub 2010 Jul 15.PMID:20634354
  • Rector RS, Thyfault JP, Uptergrove GM, Morris EM, Naples SP, Borengasser SJ, Mikus CR, Laye MJ, Laughlin MH, Booth FW, Ibdah JA.,Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model., J Hepatol. 2010 May;52(5):727-36. Epub 2010 Mar 4.
  • Booth FW, Laye MJ., The future: genes, physical activity and health., Acta Physiol (Oxf). 2010 Aug;199(4):549-56. Epub 2010 Mar 24. Review.PMID: 20345416
  • Bunker AK, Arce-Esquivel AA, Rector RS, Booth FW, Ibdah JA, Laughlin MH.,Physical activity maintains aortic endothelium-dependent relaxation in the obese type 2 diabetic OLETF rat., Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1889-901. Epub 2010 Mar 19.
  • Rector RS, Uptergrove GM, Borengasser SJ, Mikus CR, Morris EM, Naples SP, Laye MJ, Laughlin MH, Booth FW, Ibdah JA, Thyfault JP., Changes in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF rats., Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1179-87. Epub 2010 Mar 16.,PMID: 20233940
  • Krogh-Madsen R, Thyfault JP, Broholm C, Mortensen OH, Olsen RH, Mounier R, Plomgaard P, van Hall G, Booth FW, Pedersen BK., A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity., J Appl Physiol. 2010 May;108(5):1034-40. Epub 2009 Dec 31. Erratum in: J Appl Physiol. 2010 May;108(5):1034. PMID: 20044474

Published by Dalton Cardiovascular Research Center, 134 Research Park Dr., Columbia, MO 65211
Phone: 573-882-7588 | Fax: 573-884-4232 | Email: dalton@missouri.edu